Ruthie Levi and her husband, Bob Carroll, are both fully vaccinated against Covid-19.

But while Ms. Levi is excited for a black-tie wedding the couple will attend near their home in Teaneck, N.J., in May, Mr. Carroll is already plotting his possible escape. If he sees unmasked guests mingling indoors, Mr. Carroll, who is 62 and a rabbi, says he plans to go home.

Ruthie Levi and her husband, Bob Carroll, at Thanksgiving in 2019. They are both fully vaccinated but still have different comfort levels about social gatherings.

Millions of newly vaccinated Americans are starting to organize and get invitations for the weddings, family reunions and retirement parties that dried up in the coronavirus pandemic. And many are finding the transition back to group social gatherings is tricky, requiring delicate negotiations with friends or relatives who have different comfort levels with the world these days. New sensitive topics run the gamut from where to gather to whether to allow children or others who haven’t had a vaccination.

Ashley Stevens, who is 35 and a college counselor in Richmond, Va., says she and a cousin recently spoke by phone about how to celebrate Mother’s Day, since they and their relatives will be vaccinated. Her cousin envisioned a sizable weekend getaway, with family coming in from various locations, but Ms. Stevens says she thought a much simpler gathering would be safer for now.

“The argument,” Ms. Stevens says, “went from arguing to crying.”

They decided to meet in pods of immediate families and then connect digitally via the social-networking app Houseparty.

“These negotiations with everyone are going to happen as the country opens up more,” Ms. Stevens says. “You’re going to argue.”

The nation’s Covid-19 vaccine campaign continues to gain ground, with more than 50% of U.S. adults having received at least one vaccine dose, according to data from the Centers for Disease Control and Prevention. Yet officials have voiced concern about the level of U.S. Covid-19 infections, and about the coronavirus variants sweeping across the world.

The CDC has given the green light to small gatherings of vaccinated people but says even the fully inoculated should continue to wear masks in many situations and follow hand-washing and social-distancing guidelines to prevent post-vaccine infection.

“Re-entry anxiety” around social interactions is understandable, Cleveland Clinic psychologist Susan Albers says. People have fallen out of practice with socializing and now are coming together with varying boundaries and safety concerns. Guidelines are changing often, and “we’re still adjusting to figure out what feels safe and what feels OK,” she says.

“My advice is that you don’t have to dive right in,” Dr. Albers says. “Put your toe in and kind of get used to this new environment.”

Talk of a four-day family reunion in Florida was too much, too soon, Ashley Jamieson, a 33-year-old lawyer in Washington, D.C., says. She was startled when she saw relatives, in a group text, propose one for late July, she says.

Ashley Jamieson, a lawyer in Washington, D.C., plans to skip a large family reunion in July and get together with her mother and sisters in August instead.

She will skip the reunion and instead meet up with her mother and two sisters in August.

Britney Forbes and her fiancé put off a big wedding last year due to Covid-19 and got married in a backyard ceremony instead. But Ms. Forbes, a 30-year-old graphic designer in the New York City area, never nixed the idea of her dream wedding and is now planning a reception at Foxwoods Resort Casino for this fall.

The young couple is on their way to being fully vaccinated, yet figuring out how to hold a large event in the pandemic is still nerve-racking, and she says they’ve been split on whether to host it all. She would like to make it work, although she says she has conflicting feelings. She doesn’t want to put anyone’s family in danger, and envisions tough logistics, including making sure guests from across the country are healthy and aren’t coming from a virus hot spot. She also thinks she would have to confront a member of the wedding party who isn’t planning to get vaccinated.

“I will tell them to their face, ‘You just flat out can’t come,’ ” Ms. Forbes says. “I don’t think about myself like a Bride-Zilla in any way, but this is something that I have pretty strong opinions on.”

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